The Viscotek Model 302-050 Tetra Detector Array is a revolutionary, integrated multiple-detector device designed for the characterization of natural and synthetic polymers and copolymers, proteins, protein conjugates, excipients and other macromolecules. In a
single GPC/SEC experiment, the Tetra Detector will provide:
Absolute molecular weight without the assumptions, extrapolations or corrections required by alternative techniques
-
Molecular size expressed as Hydrodynamic Radius (Rh) to less than 1 nm and Radius of Gyration (Rg).
-
Intrinsic viscosity or molecular density.
-
Information on structure, conformation, aggregation,
branching and copolymer or conjugate composition.
The Model 302-050 Tetra Detector Array consists of a Differential Refractive Index (RI) Detector, UV, four-capillary Differential Viscometer Detector and a Low Angle Light Scattering (LALS) Detector. All the detectors reside within a temperature-controlled compartment which also has space for 3-5 analytical GPC columns. This arrangement minimizes inter-detector volumes to reduce band-broadening effects and insures that detectors, inter-detector tubing, columns and sample reside at the same temperature throughout the course of the analysis.
The detectors in the Tetra Detector Array are arranged in a unique series configuration as follows: UV– light scattering - differential refractometer – differential viscometer. This configuration, with the viscometer placed after the RI, eliminates viscometer dilution effect and break-through, hence increasing sample throughput capability and efficiency of operation.
